Correlation analysis revealed that GLRX and CD58 were negatively correlated with hypoxia score in PCOS, and all six hub genes were negatively correlated with hypoxia score in RA, and CSTA, DPH3, CAPZA2 and GLRX were negatively correlated with angiogenesis score (Figures 7E,F). The gene discussed is CSTA; the disease is rheumatoid arthritis.