Obesity increases renal reabsorption of sodium and water, leading to increased extracellular matrix, resulting in glomerulosclerosis and glomerular hypertrophy, leading to conditions such as hypertension and glomerular hyperfiltration, activating the renin‐angiotensin‐aldosterone system (RAAS) and the sympathetic nervous system, ultimately resulting in hypertension and kidney damage.37 The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.