KEGG pathway enrichment analysis disclosed that the main pathways co‐enriched by both groups of Hub genes included T cell receptor signaling pathway, PD‐L1 expression, and PD‐1 checkpoint pathway in cancer, Th1 and Th2 cell differentiation, Chagas disease, Th17 cell differentiation, epstein‐barr virus (EBV) infection, human immunodeficiency virus 1 infection, and other metabolic pathways (Figure 5). This evidence concerns the gene CD274 and Chagas disease.