Interestingly, in Brown et al., CAR-T levels in the blood but not in the CSF showed a significant positive correlation with LAG3 and a significant negative correlation with exhaustion markers PD-1 and CD57.13 This seemingly paradoxical relationship is relevant clinically as glioblastoma is known to induce T-cell expression of LAG3 and PD-1 and downregulate pro-inflammatory pathways such as IFN-γ. The gene discussed is LAG3; the disease is glioblastoma.