GPX8 and neoplasm: Upregulated ALDH1L2 facilitates one-carbon folate metabolism to produce NADPH, which not only acts as a reducing agent to promote nucleotide biosynthesis, but also enhances antioxidant defenses (Lee and Vousden, 2024), along with elevated GPX8-driven glutathione metabolism that helps manage oxidative stress responses crucial for tumor cell survival (Li et al., 2022).