The oncogenic components, namely, ALDH1B1, ALDH1L2, CHSY1, CSGALNACT2, and GPX8, were progressively upregulated in more aggressive tumors, while the tumor suppressor hubs FBP1 and HPGD were downregulated as tumor aggressiveness increased (Figure 3A). The gene discussed is HPGD; the disease is neoplasm.