Increased CHSY1 and CSGALNACT2 expression remodels the extracellular matrix (ECM) through glycosaminoglycan biosynthesis (Zeng et al., 2018; Wu et al., 2021), whereas downregulation of HPGD induces prostaglandin-driven inflammation (Sun et al., 2021), both of which are critical for tumor progression. Here, HPGD is linked to neoplasm.