(155) found that IGFBP-6 expression significantly increased in primary myelofibrosis (PMF), and IGFBP-6 stimulated the up-regulation of CAFs markers α-SMA, FAP, and TGF-β expression in human bone marrow stromal cells HS5, suggesting that IGFBP-6 could stimulate the transformation of MSCs into CAFs and might be correlated with the progression of myelofibrosis. This evidence concerns the gene IGFBP6 and myelofibrosis.