SERPINE1 and gastric cancer: In the study of gastric cancer (GC), adipocytes, when co-cultured with GC cells, significantly increased the expression levels of CAFs markers FSP-1, inflammatory cytokines, PAI-1, and IL-6, while the invasiveness of GC cells was enhanced, suggesting that adipocytes can acquire the CAFs phenotype under the stimulation of GC cells, which further promotes the invasion process of GC cells (41).