IL6 and cancer: In terms of tumor invasion and metastasis, CAFs stimulate the invasion and metastasis of cancer cells by promoting epithelial mesenchymal transformation (82, 83), overexpressing its own markers (24, 48), or secreting of growth factors (23, 84), cytokines such as IL1β/IL-1R (85–87), IL-6 (88), IL-11 (89), IL-17a (90), IL-22 (91) and leukemia inhibitory factor (92), chemokine receptors (93), adhesion factors (94, 95), exosomes (96–102), and various metalloproteinases (MMPs) (23, 71, 88).