In another study, Frassanito et al (146) showed that the expression levels of CAFs markers (FSP-1, α-SMA, FAP) in bone marrow of patients with active MM were obviously higher than those in patients with MM remission, patients with monoclonal gammopathy of undetermined significance, and patients suffering from iron deficiency anemia. This evidence concerns the gene S100A4 and Miyoshi myopathy.