Thrombospondin-1 (TSP-1): TSP-1, an ECM glycoprotein, highly regulates hepatic stellate cell activation and fibrosis in NAFLD/NASH; meanwhile, TSP-1 deficiency prevents various NASH phenotypes (Min-DeBartolo et al., 2019). The gene discussed is THBS1; the disease is metabolic dysfunction-associated steatohepatitis.