SIDT2 and metabolic dysfunction-associated steatotic liver disease: Sidt2 knockout models exhibit significant lipid metabolic disorders and spontaneous NAFLD development, accompanied by transmissible endoplasmic reticulum stress (TERS), suggesting potential interactions with lactoferrin’s lipid-regulating pathways (Gu et al., 2021; Qian et al., 2023; Moon et al., 2018).