Olfactomedin 2 (OLFM2): This adipose tissue-derived glycoprotein modulates hepatic lipid metabolism and mediates significant interactions between subcutaneous adipose tissue (SAT) and the liver, emphasizing its importance in NAFLD pathogenesis (Barrientos-Riosalido et al., 2023). The gene discussed is OLFM2; the disease is metabolic dysfunction-associated steatotic liver disease.