Our research revealed that the expression of TRPC3 gradually decreased with the increase in hyperoxia exposure time, which may be related to the reduction of the number of cells in lung tissue due to the simplification of alveolar and pulmonary blood vessels in BPD, and the decrease in Ca2+ influx caused by the decrease in cell proliferation and anti‐inflammatory response caused by the decrease of TRPC3 may aggravate the occurrence of BPD. This evidence concerns the gene TRPC3 and bronchopulmonary dysplasia.