Given this result, we further analyzed the immune profiles in major peripheral organs that coordinate systemic immunity, using the same CT26 tumor model and treatment schedule as in Fig. 6A. aPD-1@PMPNs significantly elevated the concentration of IFN-γ in the serum, indicating a proinflammatory environment fostered beyond the local tumors (Fig. 7D) [40]. This evidence concerns the gene IFNG and neoplasm.