determined that cerebral ischaemia–reperfusion suppresses the expression of the m6A demethylase ALKBH5 but increases the expression levels of SNHG3 and PANoptosis-related proteins and that ALKBH5 overexpression and SNHG3 deficiency suppress PANoptosis, indicating that ALKBH5 may exert its protective effect through the inhibition of SNHG3-mediated PANoptosis to reduce IRI [59]. Here, ALKBH5 is linked to ischemia.