As shown in Figure 8C, correlations among six key genes (AKR1C3, NPC1, ABCB1, EIF2AK2, IFIH1, SCO2), AOS levels, ROS levels, and three key metabolites (L-glutamate, 5′-methylthioadenosine, α-tocopherol) were evaluated in both HC and SLE groups. This evidence concerns the gene AKR1C3 and systemic lupus erythematosus.