Despite the limitation using CD11c-Cre mice, our bulk RNA-seq analysis demonstrated divergent transcriptomic changes and differentially impacted pathways in TR-AMs and Mo-AMs purified from the fibrotic lungs of miRNA-deficient mice, which provides some interesting clues on miRNA differential regulation in AM subtype behaviors during lung fibrosis. Here, ITGAX is linked to pulmonary fibrosis.