Moreover, our bulk RNA-seq data showed a mild increase (1.34-folds change, FDR = 0.049) in the PPAR-γ mRNA level and comparable mRNA levels of GM-CSF receptors (Csf2ra and Csf2rb) of Mo-AMs from Dicer cKO mice compared to the WT control, suggesting that BLM-induced GM-CSF could efficiently drive the differentiation of MOs into Mo-AMs in the absence of miRNA regulation. The gene discussed is CSF2RA; the disease is Bloom syndrome.