CD4 and neoplasm: In most tumors, resting memory CD4 T cells, resting NK cells, M2 macrophages, and neutrophils positively correlated with PKNOX1, whereas plasma cells, CD8 T cells, regulatory T cells, and activated NK cells negatively correlated with PKNOX1 (Figure 7A), suggesting that PKNOX1 may be associated with tumor immunosuppression.