reported that the lncRNAs such as ADAMTSL4-AS1, SOCS2-AS1, and AC067931 were strongly overexpressed in HCC tissues and PBMCs, and the HCC is also differentiated from the chronic hepatitis B (CHB) and liver cirrhosis (LC) when combined with alpha-fetoprotein (AFP) confirmed by a qRT-PCR analysis. Here, AFP is linked to chronic hepatitis B virus infection.