Last but not least the upregulated lncRNA MAPKAPK5_AS1 in HBV-related HCC tissues promotes the transcription of CDK4/6 and S-phase kinase-associated protein 2 (Skp2) by interfering with extra-cellular signal-regulated kinase (ERK) pathway mediated degradation of c-Myc protein (76). Here, MYC is linked to hepatocellular carcinoma.