Similarly, upregulated Urothelial Cancer Associated 1 (UCA1) was also observed to be increased after HBx in HBV-associated HCC, and promotes tumor growth and metastasis via recruiting EZH2 and repressing p27Kip1/CDK2 signaling in patients with chronic HBV (44). The gene discussed is EZH2; the disease is hepatocellular carcinoma.