It is also evidenced that HULC positively regulates cellular growth and modulates various signaling pathways such as MAPK, NF-κB, PI3K/AKT, Wnt/β-catenin, and Hippo by sponging the miRNAs miR-101, miR-200a, miR-372, miR-34a, miR-186 respectively and involves in HCC progression (42). The gene discussed is AKT1; the disease is hepatocellular carcinoma.