Likewise, HOX Transcript Antisense RNA (HOTAIR), which was originally detected in other types of cancer, is particularly upregulated in HBV-associated HCC owing to the activation of HBx via two transcriptional repressive complexes such as Polycomb Repressive Complex 2 (PRC2) & lysine-specific demethylase 1/corepressor/RE1-silencing transcription factor (LSD1/CoREST/REST) complex respectively. Here, HOTAIR is linked to hepatocellular carcinoma.