CUL3 and Hirschsprung disease: detected the downregulation of miR‐141 expression in colon tissues of HSCR patients accompanied by increased expressions of CD47 and cullin 3 (CUL3) through real‐time quantitative polymerase chain reaction (PCR) and western blotting and confirmed the hypermethylation of CpG island in the promoter region of the miR‐141 gene.