For example, SIRT4 can enhance the drug sensitivity of colorectal cancer cells to 5‐FU and oxaliplatin; SIRT4 can enhance the sensitivity of breast cancer cells to tamoxifen, etc. In conclusion, whether it is the regulation of energy metabolism in tumor cells by SIRT4 or exerting certain therapeutic effects on tumors through synergistic glutamine metabolism and synergistic antitumor drugs, it indicates that the effects of SIRT4 on tumor cells have certain research prospects. The gene discussed is SIRT4; the disease is colorectal cancer.