Silencing of UHRF1 significantly inhibited aerobic glycolysis in pancreatic cancer cells, while further analysis showed that SIRT4, a downstream target of UHRF1, and inhibition of SIRT4 by UHRF1 could, in turn, promote aerobic glycolysis,25 which at the same time left us with the question, “whether increasing the activity of SIRT4 could inhibit aerobic glycolysis in tumor cells?” Of course, it remains to be verified by studies. The gene discussed is SIRT4; the disease is pancreatic neoplasm.