SIRT4 and hepatocellular carcinoma: showed that SIRT4 acts as a tumor suppressor by regulating glutamine metabolism in hepg2 hepatocellular carcinoma cells and PC3 human prostate cancer cells, and SIRT4 knockout mice spontaneously developed lung cancer38; SIRT4 was expressed lower than average tissue in bladder cancer, T‐cell leukemia, lung cancer, ovarian cancer, breast cancer, liver cancer, laryngeal squamous cell carcinoma, thyroid cancer, and other tumors, suggesting that SIRT4 may have a tumor suppressor role in some cancers.