SIRT4 and colorectal cancer: found that SIRT4 was significantly downregulated in colorectal cancer tissues through analysis of 89 colorectal cancer cases and that SIRT4 also increased the sensitivity of colorectal cancer cells to the chemotherapeutic drug 5‐fluorouracil through cell cycle inhibition48; subsequently, in a study on colorectal cancer (CRC), researchers noted that SIRT4 might enhance the sensitivity of CRC cells to 5‐FU and oxaliplatin chemosensitivity.54