While the population of tumor-infiltrating CD8+ T cells was only minimally affected (Fig. 3G), DS treatment markedly increased the population of M1-polarized macrophages (MHC-II+ CD206−) and decreased the proportion of M2-polarized TAMs (MHC-II− CD206+) (Fig. 3H), suggesting a shift toward a pro-inflammatory, tumor-suppressive phenotype. The gene discussed is CD8A; the disease is neoplasm.