Activity VitB6 rescues DNA damage treating impaired PI3K, so it can enhance insulin sensitivity and attenuating insulin resistance (Mascolo et al. 2022), and VitB6 has been proved that VitB6 can induced autophagy inhibiting the apoptosis of β‐cells (Zhang et al. 2022) via the mTOR‐dependent pathway. Here, MTOR is linked to Insulin resistance.