The VitB6 (300 mg per day) were proved to decreasing the level of indicator such as the fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), fasting serum insulin and homeostasis model assessment of insulin resistance (HOMA‐IR) in DM patients (Dawood et al. 2023), and significantly decreasing the postprandial blood glucose in healthy individuals (Kim et al. 2019). Here, INS is linked to diabetic maculopathy.