Similarly, research by Radin et al. (2008) demonstrated that knockout of TLR4 or treatment with TLR4 inhibitors (e.g., TAK-242) in adipocytes significantly reduced the expression of cholesterol-induced proinflammatory cytokines and restored insulin signaling activity, suggesting a negative correlation between the TLR4 pathway and the development of insulin resistance. This evidence concerns the gene TLR4 and Insulin resistance.