In the case of BOLA2B and RPS4Y1, although a direct association between NEC and BOLA2B or RPS4Y1 has not been reported, functional analysis showed that BOLA2B was enriched in pathways associated with cell cycle inhibition,18 which may inhibit intestinal cell proliferation leading to disruption of the intestinal barrier and thereby increase the severity of NEC. The gene discussed is BOLA2B; the disease is necrotizing enterocolitis.