In 2016, the first study of the DNA methylome of stage 4S revealed the unique methylation pattern of stage 4S18; in 2022, high expression of E2 transcription factor 3 (E2F3) was associated with poorer survival in 134 stage 4S patients,19 and these will contribute to the study of spontaneous regression of NB. This evidence concerns the gene E2F3 and neuroblastoma.