A recent study by Das et al. [13] demonstrated that activation of the TGF-β-ERK1/2-mTORC1 axis plays a key role in promoting podocyte injury and proteinuria in experimental models of glomerular disease, highlighting the pathogenic relevance of these signaling pathways in glomerular permeability and sclerosis. Here, TGFB1 is linked to glomerular disorder.