Given the aberrant differentiation of NB cells, treatment to induce NB cell differentiation has proven to be an effective therapeutic strategy, and recently, several differentiation‐related targets have been identified, including AHR, HDAC1/2, and EZH2, which provide the basis for the development of differentiation therapeutic strategies.35, 36, 37. The gene discussed is EZH2; the disease is neuroblastoma.