CD4 and adenoviridae infectious disease: Although we have not identified which cells produce IFNγ in the β-glucan model, it has been demonstrated by our group and others that following BCG vaccination, CD4+ T cells are the major source of IFNγ (Tran et al., 2024), whereas after pulmonary adenovirus infection, CD8+ T cells predominantly produce IFNγ (Yao et al., 2018).