PTPN2 and inflammatory bowel disease: We previously demonstrated that constitutive Ptpn2-KO mice displayed microbial dysbiosis and expansion of adherent-invasive E. coli (AIEC).37 Given that CEACAM6 in IECs is the recognized receptor for AIEC, we wanted to determine the expression of CEACAM6 in the intestinal biopsies of IBD patients genotyped for PTPN2 loss-of-function SNP rs1893217.