TSG101 and breast cancer: Consistent with findings from previous reports that TSG101 is essential for the growth of breast cancer cells in culture [25, 26], the results from this study demonstrate a perpetual pro-tumorigenic function of TSG101 for the proliferation and survival of adenosquamous carcinoma cells in established tumors, suggesting that TSG101 might serve as a rational molecular target to prevent and treat a subset of mammary tumors.