They reported that HCV patients had a higher mean age (65.9 ± 1.3 years versus 61.5 ± 1.4 years, P-value 0.04), Moreover, those patients with HCV showed a higher prevalence of cryoglobulinemia (60% versus 10%, P- value 0.001), and hypocomplementemia (60% versus 8%, P- value 0.001), and a lower prevalence of anti-Ro/SS-A (17% versus 38%, P- value 0.03) when compared with SjD patients. Here, CALR is linked to cryoglobulinemia.