Patients with both HCV and sicca manifestations (compared with SjD without HCV) had a higher frequency of RF (56% vs. 40%, P-value 0.004), serum monoclonal gammopathy (47% vs. 17%, P-value < 0.001), and cryoglobulinemia (61% vs. 7%, P-value < 0.001); a lower frequency of ANA (76% vs. 84%, P-value 0.05), anti-Ro (15% vs. 43%, P-value < 0.001), and anti-La (17% vs. 30%, P-value < 0.001). The gene discussed is CALR; the disease is monoclonal gammopathy.