Notably, we found eight proteins shared by stroke and epilepsy (e.g., SH3BGRL3, PTPMT1), nine shared by epilepsy and VaD (e.g., DOCK7, BCAN), and ten by stroke and VaD (e.g., MTHFR, UVRAG), suggesting common pathogenic axes like inflammation and cellular stress. The gene discussed is MTHFR; the disease is Stroke.