The genes that currently lack a direct association with ischemic stroke include PPP5C, KTN1-AS1, CTB-50L17.9, ZNF362, ZIK1, ELP5, CKAP2, NUP88, SEC16A, TPGS2, ZNF683, SCAND1, and FBXL12. Here, FBXL12 is linked to ischemic stroke.