MTHFR and stroke disorder: Notably, we found eight proteins shared by stroke and epilepsy (e.g., SH3BGRL3, PTPMT1), nine shared by epilepsy and VaD (e.g., DOCK7, BCAN), and ten by stroke and VaD (e.g., MTHFR, UVRAG), suggesting common pathogenic axes like inflammation and cellular stress.