In conclusion, this study demonstrated that BYHWD alleviated energy metabolism dysfunction caused by CIRI through regulating the SIRT1/AMPK pathway, increasing glucose uptake, and improving glycolysis and TCA cycle function (Fig. 8). These findings deepen our understanding of the pharmacological mechanisms of BYHWD and provide insights into TCM strategies for preventing and treating cerebral infarction. Here, SIRT1 is linked to brain infarction.