CD8A and neoplasm: These results suggest that IBC tumour-infiltrating T cells have large differences in terms of cellular function and status compared with nIBC cells, which is mainly reflected in the fact that IBC tumour-infiltrating T cells have a more pronounced CD8 + T-cell immune response but also show greater activation of signals from immunosuppressive states, such as the CD4_Treg and CD8_Tex cell statuses.