Our differential enrichment analysis of all B cells in IBC and nIBC revealed that IBC tumour-infiltrating B cells have a high level of immunoreactive signals, including myeloid dendritic cell activation, positive regulation of monooxygenase activity, and major histocompatibility complex (MHC) class II biosynthetic processes (Extended Data Fig. S3a), in which IFNG and GNLY were significantly overexpressed in B cells of IBC (Extended Data Fig. S3b). The gene discussed is IFNG; the disease is neoplasm.