We found a strong correlation between the expression of DUSP2 and DUSP5 in the direction of differentiation of HER2 + IBC tumour-infiltrating antibody-secreting cells and the putative chronology of differentiation by putative chronology analysis, which suggests that HER2 + IBC tumour-infiltrating B cells may contribute to the formation of an immunosuppressive microenvironment through a more active process of extrafollicular differentiation. The gene discussed is DUSP5; the disease is neoplasm.