First, when tumour-infiltrating B cells and endothelial cells were scored on the basis of a set of six TNF-related gene sets, we found that TNF-related pathway scores were higher in both IBC tumour-infiltrating B cells and endothelial cells than in nIBC, with the positive regulation of tumour necrosis factor mediated signalling pathway differences being most pronounced in B cells (Fig. 7a). Here, TNF is linked to neoplasm.