In this study, we constructed single-cell landscapes of the TME for the HER2 + molecular subtypes of IBC (3 patients, 15,832 cells) and nIBC (9 patients, 49,574 cells) while also integrating single-cell landscapes of normal breast tissue (5 patients, 14,767 cells) to identify the specific characteristics of the IBC TME. Here, ERBB2 is linked to inflammatory breast carcinoma.