To explore the TME of IBC patients and clarify the changes in their cellular components and molecular characteristics, we integrated single-cell data from three sources of breast tissues, including 3 patients with HER2 + IBC (self-assessed data from this study), 9 patients with HER2 + nIBC (GSE176078 and GSE161529), and 5 NBT (normal breast tissues, GSE161529 and GSE164898). This evidence concerns the gene ERBB2 and inflammatory breast carcinoma.