For example, SCN1A-associated Dravet syndrome variants exhibited 3D positional correlations with SCN2A variants associated with autism (R = 0.31, P = 4.7e − 35), and Brugada syndrome variants in SCN5A (R = 0.29, P = 6.1e − 40). This evidence concerns the gene SCN2A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.