In a study, the combination of an EGFR-targeting oncolytic adenovirus (Onc.Ad-EGFR BITE) with folate receptor-alpha (FR-α)-specific CAR-T cells demonstrated improved tumour cell killing through the secretion of bispecific T-cell engagers (BITE) in pancreatic and colorectal carcinoma [416]. The gene discussed is FOLR1; the disease is colorectal carcinoma.