The intracellular signalling domain is distinct from those found in CAR-T and CAR-NK cells, incorporating macrophage-specific elements such as Fc receptor γ-chain (FcRγ) or Megf10 to enhance phagocytosis, CD3ζ for immune activation, and MerTK or Bai1 to promote macrophage-mediated tumour elimination. Here, MERTK is linked to neoplasm.