We analysed transcripts relevant to DNA repair (Parp1), MAPK signalling (Braf, Mapk1, Rasgrp2) and cell cycle progression (Ccnt2, Ccnk, Cdk5, E2f1, Cdc45) and Vps16. In all cases, transcripts from AML cells with a recombined Rnpc3 locus exhibited elevated minor intron retention compared to cells in which the Rnpc3 locus remained intact (Fig. 4D). The gene discussed is CCNK; the disease is acute myeloid leukemia.