Antral adenomas harvested from TMX-treated Tff1-CreERT2;Rnpc3lox/lox;Gp130F/F mice contained 50% less Rnpc3 mRNA than antral adenomas from TMX-treated Rnpc3lox/lox;Gp130F/F (no Cre-transgene) controls (Fig. EV2H). This evidence concerns the gene RNPC3 and adenoma.