We surmise from this that the reduction in adenoma burden observed in TMX-treated Tff1-CreERT2;Rnpc3lox/lox;Gp130F/F mice is likely due to the combined effect of two induced genotypes: the Rnpc3lox/Δ (heterozygous) genotype causing reduced proliferation and the Rnpc3Δ/Δ (homozygous null) genotype causing cell death. This evidence concerns the gene TFF1 and adenoma.