TP53 and hepatocellular carcinoma: Compared to rnpc3+/+;TO(krasG12V)Tg/+ livers expressing WT tp53 alleles (Fig. 2B,C, blue circles), mean liver volume was increased by 33% on a tp53m/m background (Fig. 2B,C, red squares), indicating that Tp53 normally restricts liver overgrowth in the zebrafish HCC model.