Mice with a Rnpc3+/−;Gp130F/F genotype exhibited a significant reduction in total adenoma weight compared to Rnpc3+/+;Gp130F/F mice at both 100 and 180 d, with a more marked reduction in the weight of adenomas harvested from the proximal glandular epithelium (corpus; arrowheads) compared to the distal glandular epithelium (antrum; arrows, Fig. 3E–G). This evidence concerns the gene RNPC3 and adenoma.