EGFR and FGF2 are highly expressed in up to 60–90% of HNSCC tumors46,47, and Marianne et al. revealed that frequent coexpression of FGF2 and FGFRs in HNSCC cell lines, thereby instituting an autocrine loop that, alone or in collaboration with EGFR, drives cell growth46. This evidence concerns the gene FGF2 and head and neck squamous cell carcinoma.