Specifically, we observed elevated levels of MAPK (p-ERK-T202-Y204), Vimentin, YAP (pS127), AMPK (pT172), eIF4G, Myosin-IIa (pS1943), Stat3 (pY705) and B-Raf (pS445), suggesting that M2 macrophage-derived exosomes induce various oncogenic signaling pathways in pancreatic cancer cells. This evidence concerns the gene BRAF and pancreatic neoplasm.