The DNA damage repair-related pathway has been recognized as a promising therapeutic target in CRC, and the drug development efforts in this field have progressed into the early stages of clinical translation.56 Interestingly, another critical feature of the CUT&Tag data and the RNA-seq data is the considerable enrichment of nuclear TfR1 target genes in the DNA damage repair-related pathway, especially the NER pathway. Here, TFRC is linked to colorectal carcinoma.