TFRC and colorectal carcinoma: For example, TfR1-mediated iron uptake has been demonstrated to facilitate CRC cell proliferation through activation of the β-catenin/c-Myc/E2F1/POLD1 signaling pathway.13 Although the classical function of TfR1 has been comprehensively studied, ongoing research on its non-classical functions persists, as exemplified by the activation of the NF-κB signaling pathway via interacting with the IκB kinase complex,14 the regulation of gene expression through alternative splicing,15–17 the maintenance of intestinal homeostasis,18 and so forth.