With respect to mechanism underlying reduced stroke volume in iBEC-G153-KO, histological analyses showed reduced VCAM1 expression in the infarct periphery in iBEC-G153-KOs (Fig. 9H, I), and the number of neutrophils that had extravasated into the brain parenchyma was reduced (Fig. 9J, K). The gene discussed is VCAM1; the disease is stroke disorder.