Upon further investigation, we found that Huaier treatment resulted in a significant increase in NCOA4 protein levels and a decrease in FTH1 protein levels in the three distinct lung cancer cell lines consistently (Figs. 4a, b, and S4a–d), but did not alter the transcription level of these genes in these cell lines (Fig. S4e). Here, NCOA4 is linked to lung carcinoma.