T-LGLL患者存在特征性免疫谱系,表现为免疫稳态的失衡,突出的特征为效应CD8+ T细胞异常活化伴数量增加,Treg细胞数量减少且功能失调;APC及NK细胞正向调控T淋巴细胞激活、分化和增殖。. This evidence concerns the gene CD8A and T-cell large granular lymphocyte leukemia.