Angiopoietin-like 4 (ANGPTL4), the second most upregulated matrisome-associated protein (Table 4), also regulates angiogenic activation through changes in EC metabolism (63), and its increased expression in response to chronic intermittent hypoxia has been proposed as a mechanistic link between obstructive sleep apnea and increased cardiovascular risk (64). The gene discussed is ANGPTL4; the disease is obstructive sleep apnea syndrome.