SLAMF1 and Parkinson disease: Here, we identify two upregulated secretory pathways, the release of SLAM-EVs and exosomes, that work in tandem to mediate export of cellular waste and intercellular communication, respectively, in PD-neurons facing autophagic stress (Fig. 6E); we propose that the increased secretion is a compensatory response to the inhibition of autophagy observed in this model (7, 16).