SYK and Dengue hemorrhagic fever: In this study, we identified of Syk as a core node bridging immune responses (cytokine secretion) and coagulation/hemorrhage processes (Figure 6F), as well as the regulation role of Syk to cytokine storm network by protein–protein interaction (PPI) analysis (Figure 6G), substantiate the existing pathogenic hypothesis of DHF: Cytokine storms can directly disrupt endothelial tight junctions, significantly increasing vascular permeability and triggering hemorrhage with multi-organ dysfunction [35, 40–44].