This study demonstrated that the Th2-biased cytokine storm pattern observed in hTim4 mice with DENV-2 infection, characterized by elevated levels of Il6 (**P = 0.0082), Il9 (P = 0.3965), Il10 (*P = 0.0168), was highly consistent with the serum profiles of clinical dengue fever patients (Figure 7). Here, IL6 is linked to dengue disease.