Immunomodulatory network analysis revealed distinct correlation patterns between hub CRGs (CIRBP/USP30) and immune infiltration profiles in MG patients: correlation analysis demonstrated both CRGs exhibited positive associations with naïve CD4+ T cells, naïve B cells, neutrophils, M0 macrophages, and eosinophils, while inversely correlating with activated memory CD4+ T cells and plasma cells. Here, CD4 is linked to myasthenia gravis.