Given the reported roles of Isg20 in lupus nephritis [39] and clear-cell renal-cell carcinoma [42], our results highlight the pivotal and multifaceted roles of Isg20 in renal disorders; furthermore, Isg20 likely facilitates ribosome biogenesis to promote renal fibrosis progression. The gene discussed is ISG20; the disease is clear cell renal carcinoma.