In a UUO-induced renal fibrosis model in mice, enhanced ribosome biogenesis was accompanied by a decreased level of epithelial marker E-CADHERIN [29] and increased fibrotic markers α-SMA, FIBRONECTIN, and COLLAGEN I [30,31], further suggesting the role of ribosome biogenesis in renal fibrosis and CKD. This evidence concerns the gene ACTA1 and chronic kidney disease.