TP53 and leukemia: Likewise, a recent study has also reported that ATO is capable of targeting the heat shock protein 60 (Hsp60), which triggers the disruption of Hsp60-p53 and Hsp60-survivin complexes, resulting in degradation of p53 mutants and survivin, leading to inhibition of cell proliferation and induction of apoptosis in leukaemia cells [19].