SLC34A3 and Hypercalciuria: For example, more than 80 SLC transporters have been linked torare genetic diseases, including Pendredsyndrome (mutations in pendrin (SLC26A4 gene), an anion exchange proteinfor Cl–, I– and HCO3−) and hereditaryhypophosphatemic rickets with hypercalciuria (HHRH) (loss-of-functionmutations in the sodium-phosphate cotransporter NPT2c (SLC34A3 gene)). Most SLC transporters function as passive orsecondary active transporters, and theirfunction should therefore be easy to mimic using small-molecule transmembraneion transporters.