Due to the differentmetabolic needs of cancer cells, many important transport proteinsare up- or down-regulated in cancer, making them useful therapeutictargets. In addition, a variety of neurologicaldisorders have been linked to imbalanced neurotransmitter transport.For example, Alzheimer disease, amyotrophic lateral sclerosis (ALS)and Parkinson’s disease have all been associated with downregulatedlevels of EAAT2, a glutamate transport protein.−, , ,. This evidence concerns the gene SLC1A2 and amyotrophic lateral sclerosis.