KRT8 and neoplasm: Since PyMT tumors are K8+ luminal tumors, Cre expression in Ad-K8-Cre-infected tumor cells disrupted Lsd1. By tracking YFP-marked primary and metastatic tumor cells, it was found that while LSD1-loss did not significantly alter primary tumor development, it led to increased lung metastasis, suggesting that LSD1 may play a role in suppressing tumor metastasis [54].