NLRP3 and arthritic joint disease: Besides, the expression of NLRP3 was potently correlated positively with all macroscopic arthritis changes (r = 0.9635, [95% CI of difference 0.9162 to 0.9843, p < 0.0001], r = 0.9617, [95% CI of difference 0.9122 to 0.9835, p < 0.0001] and r = 0.9756, [ 95% CI of difference 0.9436 to 0.9896, p < 0.0001], respectively) (Fig. 2A–D).