In rotenone-induced model of Parkinson’s disease (PD) in rats, FTN-SNEDDS showed enhanced neuroprotective activity, as evidenced by enhanced locomotor activity, muscle coordination, and biochemical markers such as oxidative stress factors (TBARS, nitrite, GSH, SOD, CAT) and inflammatory cytokines (TNF-α, IL-6). This evidence concerns the gene TNF and Parkinson disease.