Histopathologic analysis of 25 resected cases led to the reclassification of 8 iPCLs with wild-type GNAS: 4 as mPCNs (1 IPMN, 3 MCNs) and 4 as non-mPCNs (1 SCN, 3 pseudocysts). This evidence concerns the gene GNAS and pancreatic intraductal papillary-mucinous neoplasm.